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Microbial communities are revolutionizing many fields, from biotechnology and health to agriculture. Mathematical and computational modeling is key to fulfill this potential. In this workshop, we will learn techniques to quantitatively analyze, understand and engineer microbial communities and synthetic microbial consortia. We will cover a range of topics, from the analysis of metagenomic sequencing data, to building and simulating meta-genome-scale metabolic models and analyzing the function of synthetic consortia using statistical "structure-function landscape" approaches.
Instructions for the installation of all required software and configuration be found here. Please follow these instructions to ensure that everything works correctly before the start of the workshop.
All slides, code and data can be found here. The lectures and code can also be explored using the links below.
Day | Topic | Lecturer | Materials | |
---|---|---|---|---|
Mon AM | Intro Command Line, Cloud, Intro Sequencing, Quality Control, and Filtering | Marcel van den Broek Katarina Kruščić |
Slides Syllabus |
|
Mon PM | Amplicon Data Analysis | Milan Dragićević Alfonso Esposito |
Syllabus R script 16S data |
|
Tue AM | Metagenomics Assembly | Alfonso Esposito João Saraiva |
Slides Lecture Slides Practical |
|
Tue PM | Functional Genomics and Data Visualization | Prateek Shetty Bogdan Jovanović |
Slides Data and code | |
Wed AM | Introduction to Theoretical Models in Microbial Ecology | Timmy Paez Watson Djordje Bajić |
Slides theoretical models Jupyter Notebooks | |
Wed PM |
Practical Introduction to Metabolic Network Modeling |
Timmy Paez Watson Minke Gabriels |
Slides MFA
Slides EK | |
Thu AM | Thermodynamic Analysis of Metabolic Networks | Karel Olavarria Minke Gabriels |
Thermodynamics
Jupyter Notebooks | |
Thu PM | Resource allocation and metabolic modeling of microbial communities | Đorđe Bajić Minke Gabriels |
Jupyter Notebooks
Additional code |
|
Fri AM | Structure-Function Mapping for Microbial Consortia | Juan Diaz-Colunga Uroš Gojković |
Materials |